Clarice Starling is a top student at the FBI's training academy. Jack Crawford wants Clarice to interview Dr. Hannibal Lecter, a brilliant psychiatrist who is also a violent psychopath, serving life behind bars for various acts of murder and cannibalism. Crawford believes that Lecter may have insight into a case and that Starling, as an attractive young woman, may be just the bait to draw him out.
A jet leaves on a red-eye flight from Los Angeles to Boston. But early in the flight, ten passengers awaken to a startling realization: All of the other passengers have vanished.